(Adapted from: http://www.steves-internet-guide.com/mosquitto-tls)
To activate TLS/SSL option in Mosquitto, we need to modify the configuration file of Mosquitto and edit the TLS items in that contents.
There are standard ports for MQTT to use. TCP/IP port 1883 is reserved with IANA for use with MQTT. TCP/IP port 8883 is also registered, for using MQTT over SSL.
After Step 7 of Configuring TLS/SSL on the Mosquitto Broker, we should already have the files ca.crt in ca_certificates folder and both server.crt and server.key in the certs folder.
On Raspberry Pi, open the terminal and enter the following command:
pi@raspberrypi:~ $ sudo nano /etc/mosquitto/mosquitto.conf
Locate the line with ‘port 1883’ and add an extra listener:
# =================================================================
# Default listener
# =================================================================
# IP address/hostname to bind the default listener to. If not
# given, the default listener will not be bound to a specific
# address and so will be accessible to all network interfaces.
# bind_address ip-address/host name
#bind_address
# Port to use for the default listener.
port 1883
listener 8883
Add the following lines to define the paths for ca.crt, server.key and server.crt, and TLS version:
# -----------------------------------------------------------------
# Certificate based SSL/TLS support
# -----------------------------------------------------------------
# The following options can be used to enable SSL/TLS support for
# this listener. Note that the recommended port for MQTT over TLS
# is 8883, but this must be set manually.
#
# See also the mosquitto-tls man page.
# At least one of cafile or capath must be defined. They both
# define methods of accessing the PEM encoded Certificate
# Authority certificates that have signed your server certificate
# and that you wish to trust.
# cafile defines the path to a file containing the CA certificates.
# capath defines a directory that will be searched for files
# containing the CA certificates. For capath to work correctly, the
# certificate files must have ".crt" as the file ending and you must run
# "c_rehash <path to capath>" each time you add/remove a certificate.
cafile /etc/mosquitto/ca_cetificates/ca.crt
#capath
# Path to the PEM encoded server certificate.
certfile /etc/mosquitto/certs/server.crt
# Path to the PEM encoded keyfile.
keyfile /etc/mosquitto/certs/server.key
# This option defines the version of the TLS protocol to use for this listener.
# The default value allows v1.2, v1.1 and v1.0, if they are all supported by
# the version of openssl that the broker was compiled against. For openssl >=
# 1.0.1 the valid values are tlsv1.2 tlsv1.1 and tlsv1. For openssl < 1.0.1 the
# valid values are tlsv1.
tls_version tlsv1
Save the mosquito.conf file. Hold Ctrl + X, type Y to save changes.

Note: I’ve added an extra listener but you could use the default listener by changing the port 1883 to 8883.
Restart the Mosquitto.